3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester
CAS No.:955373-60-1
Molecular Formula:C₂₈H₂₉Cl₂N₃O₄
Molecular Weight:542.462
Hs Code.:

Synonyms:3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

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Chemical Property of 3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

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Technology Process of 3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

There total 3 articles about 3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4,5,6,7-tetrahydro-3H-benzoimidazol-5-ylamine dihydrochloride

: 955373-58-7
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2-oxo-ethyl)-malonicacid diethyl ester

: 955373-60-1
3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: 4,5,6,7-tetrahydro-3H-benzoimidazol-5-ylamine dihydrochloride; 2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2-oxo-ethyl)-malonicacid diethyl ester; With sodium cyanoborohydride; In methanol; for 3h;

With acetic acid; In methanol; at 60 ℃; for 16h;

With sodium hydrogencarbonate; In water; Saturated solution;

Reference yield:

: 94-52-0,89843-47-0
6-nitro-1H-benzo[d]imidazole

: 955373-60-1
3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; hydrogen / 5% rhodium-on-charcoal / 24 h / 80 °C / 3863.02 Torr

2.1: sodium cyanoborohydride / methanol / 3 h

2.2: 16 h / 60 °C

2.3: Saturated solution

With hydrogenchloride; hydrogen; sodium cyanoborohydride; 5% rhodium-on-charcoal; In methanol;

Reference yield:

: 886616-14-4
5-benzyloxy-2-bromomethyl-1,3-dichloro-benzene

: 955373-60-1
3-(4-benzyloxy-2,6-dichloro-benzyl)-2-oxo-1-(4,5,6,7-tetrahydro-3H-benzoimidazol-5-yl)-pyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2.1: formic acid / acetone / 24 h

3.1: sodium cyanoborohydride / methanol / 3 h

3.2: 16 h / 60 °C

3.3: Saturated solution

With formic acid; sodium cyanoborohydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; acetone;