trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester
CAS No.:955373-70-3
Molecular Formula:C₂₀H₁₇Cl₂F₆N₃O₆S₂
Molecular Weight:644.4
Hs Code.:

trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Synonyms:trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

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Chemical Property of trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

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Technology Process of trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

There total 9 articles about trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(2,6-dichloro-4-hydroxy-benzyl)-1-(4,5,6,7-tetrahydro-1H-benzoimidazol-5-yl)-pyrrolidin-2-one

: 358-23-6
trifluoromethylsulfonic anhydride

: 955373-70-3
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955373-68-9
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: With pyridine; In dichloromethane; at -30 - 0 ℃;

Reference yield:

: 886616-14-4
5-benzyloxy-2-bromomethyl-1,3-dichloro-benzene

: 955373-70-3
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955373-68-9
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

2.1: formic acid / acetone / 24 h

3.1: sodium cyanoborohydride / methanol / 3 h

3.2: 16 h / 60 °C

3.3: Saturated solution

4.1: methanol; sodium hydroxide; water / 16 h

5.1: 1,4-dioxane; water

6.1: palladium dihydroxide / methanol; ethyl acetate / 16 h

7.1: pyridine / dichloromethane / -30 - 0 °C

With pyridine; methanol; sodium hydroxide; formic acid; water; sodium cyanoborohydride; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetone;

Reference yield:

: 955373-57-6
2-(4-benzyloxy-2,6-dichloro-benzyl)-2-(2,2-dimethoxy-ethyl)-malonic acid diethyl ester

: 955373-70-3
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(3-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955373-68-9
trifluoromethanesulfonic acid 3,5-dichloro-4-[2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: formic acid / acetone / 24 h

2.1: sodium cyanoborohydride / methanol / 3 h

2.2: 16 h / 60 °C

2.3: Saturated solution

3.1: methanol; sodium hydroxide; water / 16 h

4.1: 1,4-dioxane; water

5.1: palladium dihydroxide / methanol; ethyl acetate / 16 h

6.1: pyridine / dichloromethane / -30 - 0 °C

With pyridine; methanol; sodium hydroxide; formic acid; water; sodium cyanoborohydride; palladium dihydroxide; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; acetone;