(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Base Information

Chemical Name:(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine
CAS No.:105823-10-7
Molecular Formula:C₂₂H₂₄N₂O₈S
Molecular Weight:476.507
Hs Code.:

Synonyms:(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Suppliers and Price of (2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

There total 13 articles about (2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 105823-09-4
Toluene-4-sulfonic acid (2R,11aS)-7-methoxy-2-methoxymethoxy-10-methoxymethyl-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

: 105823-11-8
Toluene-4-sulfonic acid (2R,11aS)-2-hydroxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester

: 105823-10-7
(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: With hydrogenchloride; In methanol;
DOI:10.1039/c39860000841

Reference yield:

: 83577-93-9
(2S,4R)-N-trifluoroacetyl-4-[(trifluoroacetyl)oxy]proline

: 105823-10-7
(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 6 steps

2: aq. NaHCO₃

3: di-isopropylethylamine

4: NH₃ / methanol

5: 69 percent / n-Bu₃N / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

6: 68 percent / aq. HCl / methanol

With hydrogenchloride; tributyl-amine; ammonia; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene;
DOI:10.1039/c39860000841

Reference yield:

: 615-43-0
2-iodophenylamine

: 105823-10-7
(2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine

Guidance literature:: Multi-step reaction with 6 steps

2: 92 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

3: 95 percent / NaH / tetrahydrofuran / -30 °C

4: 87 percent / NH₃ / methanol

5: 69 percent / n-Bu₃N, / Pd(PPh₃)4 / toluene / 24 h / 110 °C / 7600 Torr

6: 67 percent / HCl / methanol / 20 h / 50 °C

With hydrogenchloride; tributyl-amine; ammonia; sodium hydride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)87534-7