(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one
CAS No.:1380517-75-8
Molecular Formula:C₂₇H₂₅F₂NO₄
Molecular Weight:465.497
Hs Code.:

Synonyms:(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

There total 8 articles about (R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224104-05-5
3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoic acid

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1380517-76-9
(R)-4-benzyl-3-((R)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

: 1380517-75-8
(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

Guidance literature:: 3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

(R)-4-(phenylmethyl)-2-oxazolidinone; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 3.5h;

Reference yield:

: 28177-48-2
2,6-difluorophenol

: 1380517-76-9
(R)-4-benzyl-3-((R)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

: 1380517-75-8
(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

3.1: tetrahydrofuran / 2 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 80 °C

7.1: triethylamine; pivaloyl chloride / tetrahydrofuran / 0.5 h / 0 °C

7.2: 3.5 h / -78 - 20 °C

With water; hydrogen; pivaloyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 118276-06-5
3,5-difluoro-4-hydroxybenzaldehyde

: 1380517-76-9
(R)-4-benzyl-3-((R)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

: 1380517-75-8
(R)-4-benzyl-3-((S)-3-(4-(benzyloxy)-3,5-difluorophenyl)-2-methylpropanoyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2.1: tetrahydrofuran / 2 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 80 °C

6.1: triethylamine; pivaloyl chloride / tetrahydrofuran / 0.5 h / 0 °C

6.2: 3.5 h / -78 - 20 °C

With water; hydrogen; pivaloyl chloride; potassium carbonate; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;