2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol

Base Information

• Chemical Name: 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol
• CAS No.: 876616-89-6
• Molecular Formula: C₁₈H₂₄BNO₄
• Molecular Weight: 329.204
• Mol file: 876616-89-6.mol

Synonyms:2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol

Chemical Property of 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol

There total 1 articles about 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

bis(pinacol)diborane (73183-34-3) + 2-(4-bromophenyl)-5-methyl-4-oxazoleethanol (328918-84-9) → 2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (876616-89-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2006.09.011

Reference yield: 41.0%

2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (876616-89-6) + 2-chloropyrimidine (1722-12-9,1195939-87-7) → 2-[5-methyl-2-(4-pyrimidin-2-yl-phenyl)-oxazol-4-yl]-ethanol (918931-56-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2006.09.011

Reference yield:

2-{5-methyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-oxazol-4-yl}-ethanol (876616-89-6) + 2-(4-chlorophenyl)-5-methyl-1,3,4-oxadiazole (22815-98-1) → 2-{5-methyl-2-[4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-yl]-oxazol-4-yl}-ethanol (876616-90-9)

Guidance literature:

With potassium carbonate; palladium diacetate; tricyclohexylphosphine; In ethanol; at 90 ℃; for 4h; under 3361.55 Torr; Microwave;

upstream raw materials:

bis(pinacol)diborane

2-(4-bromophenyl)-5-methyl-4-oxazoleethanol

Downstream raw materials:

2-[5-methyl-2-(4-pyrimidin-2-yl-phenyl)-oxazol-4-yl]-ethanol

toluene-4-sulfonic acid 2-[5-methyl-2-(4-pyrimidin-2-yl-phenyl)-oxazol-4-yl]-ethyl ester

3-(2-(isopropoxycarbonylamino-methyl)-4-{2-[5-methyl-2-(4-pyrimidin-2-yl-phenyl)-oxazol-4-yl]-ethoxy}-phenyl)-propionic acid tert-butyl ester

2-{5-methyl-2-[4'-(5-methyl-[1,3,4]oxadiazol-2-yl)-biphenyl-4-yl]-oxazol-4-yl}-ethanol