methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester
• CAS No.: 757967-05-8
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.378
• Mol file: 757967-05-8.mol

Synonyms:methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester

Chemical Property of methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester

There total 1 articles about methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-aminoethyl)methylcarbamic acid tert-butyl ester (121492-06-6) + phenylacetyl chloride (103-80-0) → methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester (757967-05-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/b404946b

Reference yield:

bis-(p-nitrophenyl) carbonate (5070-13-3) + methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester (757967-05-8) → methyl-(2-phenylacetylamino-ethyl)-carbamic acid 4-nitro-phenyl ester (757967-02-5)

Guidance literature:

methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester; With trifluoroacetic acid;

bis-(p-nitrophenyl) carbonate; With triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

Reference yield:

methyl-(2-phenylacetylamino-ethyl)-carbamic acid tert-butyl ester (757967-05-8) → methyl-(2-phenylacetylamino-ethyl)-carbamic acid 4-nitro-phenyl ester (757967-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: 164 mg / Et₃N / dimethylformamide / 0.17 h

With triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1039/b404946b

upstream raw materials:

(2-aminoethyl)methylcarbamic acid tert-butyl ester

phenylacetyl chloride

Downstream raw materials:

N-(2-methylamino-ethyl)-2-phenyl-acetamide

methyl-(2-phenylacetylamino-ethyl)-carbamic acid 4-nitro-phenyl ester