2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide
CAS No.:1373128-25-6
Molecular Formula:C₁₈H₁₁F₆N₃O
Molecular Weight:399.295
Hs Code.:

Synonyms:2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

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Chemical Property of 2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

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Technology Process of 2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

There total 4 articles about 2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1153946-38-3
2,6-difluoro-N-1H-pyrazol-4-ylbenzamide

: 239087-08-2
2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

: 1373128-25-6
2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

Guidance literature:: 2,6-difluoro-N-1H-pyrazol-4-ylbenzamide; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 16h;

Reference yield:

: 1373128-30-3
1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-amine hydrochloride

: 18063-02-0
2,6-difluorobenzoylchloride

: 1373128-25-6
2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Inert atmosphere;

Reference yield:

: 239087-08-2
2-(bromomethyl)-1-fluoro-3-(trifluoromethyl)benzene

: 1373128-25-6
2,6-difluoro-N-(1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

2.2: 0.08 h

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Inert atmosphere

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;