methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

Base Information

Chemical Name:methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate
CAS No.:1283601-22-8
Molecular Formula:C₁₃H₁₃NO₅S
Molecular Weight:295.316
Hs Code.:

Synonyms:methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

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Chemical Property of methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

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Technology Process of methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

There total 3 articles about methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7744-25-4
1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one

: 79-22-1
methyl chloroformate

: 1283601-22-8
methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: 1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h; Further stages; Inert atmosphere;
DOI:10.1016/j.tet.2011.01.019

Reference yield:

: 675-20-7
piperidin-2-one

: 1283601-22-8
methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.01.019

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1283601-22-8
methyl 1-(benzensulfonyl)-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 4 h / -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.01.019