[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Base Information

Chemical Name:[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane
CAS No.:371785-34-1
Molecular Formula:C₃₃H₄₄O₂Si
Molecular Weight:500.797
Hs Code.:

Synonyms:[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Suppliers and Price of [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

There total 10 articles about [(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: {2-[5-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentyl]-cyclopropyl}-methanol

: 371785-34-1
[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; silver(l) oxide; In toluene; at 25 - 50 ℃; for 24h;

Reference yield:

: 371784-87-1
(Z)-(S)-5-Benzyloxy-2-methyl-pent-3-en-1-ol

: 371785-34-1
[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1.1: 89 percent / imidazole / dimethylformamide / 1 h / 25 °C

2.1: 75 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 10 h / 50 °C / 760.05 Torr

3.1: 93 percent / PPh₃; imidazole; I₂ / 4-DMAP / acetonitrile; diethyl ether / 1 h / 25 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 72 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 2.5 h / -78 - -30 °C

5.1: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / 25 °C

6.1: 95 percent / NaBH₄; NiCl₂; H₂ / ethylene diamine / ethanol / 1 h / 0 °C / 760.05 Torr

7.1: 99 percent / Et₂Zn; DME; cyclo-(S,S)-(n-Bu)B-[OCH(CONMe₂)]2 / CH₂Cl₂ / 6 h / 20 °C

8.1: 1.60 g / Ag₂O; TBAI / toluene / 24 h / 25 - 50 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; 1,2-dimethoxyethane; boron trifluoride diethyl etherate; hydrogen; iodine; diethylzinc; tetra-(n-butyl)ammonium iodide; triphenylphosphine; nickel dichloride; silver(l) oxide; (4S,5S)-2-butyl-N⁴,N⁴,N⁵,N⁵-tetramethyl-1,3,2-dioxaborolane-4,5-dicarboxamide; dmap; palladium on activated charcoal; ethylenediamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 7.1: Charette cyclopropanation;
DOI:10.1021/ja011338b

Reference yield:

: 371784-89-3
(S)-5-(tert-butyldiphenylsilyloxy)-4-methyl-pentanol

: 371785-34-1
[(S)-5-((1S,2R)-2-Benzyloxymethyl-cyclopropyl)-2-methyl-pentyloxy]-tert-butyl-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / PPh₃; imidazole; I₂ / 4-DMAP / acetonitrile; diethyl ether / 1 h / 25 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 72 percent / hexamethylphosphoramide / tetrahydrofuran; hexane / 2.5 h / -78 - -30 °C

3.1: 89 percent / BF₃*Et₂O / CH₂Cl₂ / 1.5 h / 25 °C

4.1: 95 percent / NaBH₄; NiCl₂; H₂ / ethylene diamine / ethanol / 1 h / 0 °C / 760.05 Torr

5.1: 99 percent / Et₂Zn; DME; cyclo-(S,S)-(n-Bu)B-[OCH(CONMe₂)]2 / CH₂Cl₂ / 6 h / 20 °C

6.1: 1.60 g / Ag₂O; TBAI / toluene / 24 h / 25 - 50 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; 1,2-dimethoxyethane; boron trifluoride diethyl etherate; hydrogen; iodine; diethylzinc; tetra-(n-butyl)ammonium iodide; triphenylphosphine; nickel dichloride; silver(l) oxide; (4S,5S)-2-butyl-N⁴,N⁴,N⁵,N⁵-tetramethyl-1,3,2-dioxaborolane-4,5-dicarboxamide; dmap; ethylenediamine; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; toluene; acetonitrile; 5.1: Charette cyclopropanation;
DOI:10.1021/ja011338b