ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Base Information

Chemical Name:ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate
CAS No.:159693-13-7
Molecular Formula:C₁₅H₉F₈NO₃
Molecular Weight:403.229
Hs Code.:

Synonyms:ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Suppliers and Price of ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

There total 3 articles about ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 129922-54-9
pentafluoro-2-pentynoic acid ethyl ester

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 159693-13-7
ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Guidance literature:: With sodium hydroxide; In dichloromethane; at -5 - 5 ℃; for 0.25h;
DOI:10.1021/jf00049a040

Reference yield: 37.8%

: 129922-54-9
pentafluoro-2-pentynoic acid ethyl ester

: (Z)-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride

: 159693-13-7
ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

: ethyl 4-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-5-isoxazolecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1002/jhet.5570400404

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 159693-13-7
ethyl 5-(pentafluoroethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 38 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

With sodium hydroxide; N-chloro-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040