2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

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Chemical Name:2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole
CAS No.:1004764-09-3
Molecular Formula:C₂₁H₂₁ClN₂O₃S₂
Molecular Weight:448.994
Hs Code.:

Synonyms:2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

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Chemical Property of 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

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Technology Process of 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

There total 6 articles about 2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1004764-08-2
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d][1,3]thiazol-3a-ol

: 1004764-09-3
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 619-57-8
p-hydroxybenzamide

: 1004764-09-3
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / ethyl acetate / 24 h / Reflux

2: Lawessons reagent / chloroform / 12 h / 22 °C

3: N,N-dimethyl-formamide / 2 h / 60 °C

4: methanesulfonyl chloride; triethylamine / dichloromethane / 12 h / 20 °C

With Lawessons reagent; potassium carbonate; methanesulfonyl chloride; triethylamine; In dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; 3: Hantzsch condensation;
DOI:10.1002/cmdc.201100248

Reference yield:

: 16851-72-2
1-[(4-methylphenyl)sulfonyl]-2,5-dihydro-1H-pyrrole

: 1004764-09-3
2-[4-(3-chloropropoxy)phenyl]-5-[(4-methylphenyl)sulfonyl]-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; water / dimethyl sulfoxide; acetonitrile / 2 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: N,N-dimethyl-formamide / 2 h / 60 °C

4: methanesulfonyl chloride; triethylamine / dichloromethane / 12 h / 20 °C

With N-Bromosuccinimide; water; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; 3: Hantzsch condensation;
DOI:10.1002/cmdc.201100248