di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate

Base Information

• Chemical Name: di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate
• CAS No.: 1394168-98-9
• Molecular Formula: C₃₄H₃₁FO₂
• Molecular Weight: 490.617
• Mol file: 1394168-98-9.mol

Synonyms:di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate

Chemical Property of di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate

There total 4 articles about di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(1-naphthyl)methanol (62784-66-1) + 2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid (180293-49-6) → di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate (1394168-98-9) + di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate (1394168-88-7)

Guidance literature:

With (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.3390/molecules17067356

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate (1394168-98-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sulfuric acid / 7.08 h / 0 °C / Reflux; Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / -78 - 0 °C / Inert atmosphere

2.2: 8 h / -78 - 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / ethanol / 3 h / 0 - 20 °C / Inert atmosphere

4.1: (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine / diethyl ether / 24 h / 20 °C / Inert atmosphere

With sulfuric acid; (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; water; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol;

DOI:10.3390/molecules17067356

Reference yield:

ethyl 2-fluoro-2-(4-isobutylphenyl)propanoate (74590-67-3) → di(naphthalen-1-yl)methyl 2-fluoro-2-(4-isobutylphenyl)propanoate (1394168-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / ethanol / 3 h / 0 - 20 °C / Inert atmosphere

2: (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine / diethyl ether / 24 h / 20 °C / Inert atmosphere

With (S)-(-)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; water; 2,2-dimethylpropanoic anhydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In diethyl ether; ethanol;

DOI:10.3390/molecules17067356

upstream raw materials:

ibuprofen ethyl ester

ibuprofen

bis(1-naphthyl)methanol

2-fluoro-2-[4-(2-methylpropyl)phenyl]propionic acid