(1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Base Information

• Chemical Name: (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester
• CAS No.: 864079-37-8
• Molecular Formula: C₁₈H₃₄O₃Si
• Molecular Weight: 326.552
• Mol file: 864079-37-8.mol

Synonyms:(1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Chemical Property of (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester

There total 3 articles about (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate (61586-78-5) → (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester (864079-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -60 - -15 °C

1.2: 90 percent / tetrahydrofuran / 4.5 h / -15 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1055/s-2005-871555

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester (864079-37-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 62 percent / NaH / benzene / 1.5 h / Heating

2.1: 76 percent / baker's yeast Saccharomyces cerevisiae; aq. sucrose

3.1: LDA / tetrahydrofuran / 0.5 h / -60 - -15 °C

3.2: 90 percent / tetrahydrofuran / 4.5 h / -15 - 20 °C

With baker's yeast Saccharomyces cerevisiae; sodium hydride; lithium diisopropyl amide; Sucrose; In tetrahydrofuran; benzene;

DOI:10.1055/s-2005-871555

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → (1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarboxylic acid ethyl ester (864079-37-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 76 percent / baker's yeast Saccharomyces cerevisiae; aq. sucrose

2.1: LDA / tetrahydrofuran / 0.5 h / -60 - -15 °C

2.2: 90 percent / tetrahydrofuran / 4.5 h / -15 - 20 °C

With baker's yeast Saccharomyces cerevisiae; lithium diisopropyl amide; Sucrose; In tetrahydrofuran;

DOI:10.1055/s-2005-871555

upstream raw materials:

ethyl (1R,2S)-2-hydroxycyclohexane-1-carboxylate

cyclohexanone

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

(1S,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexanecarbaldehyde

[(1R,2S)-1-Allyl-2-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-methanol