Technology Process of C15H18O2S
There total 5 articles about C15H18O2S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C11H14OS;
With
Jacobsen's catalyst;
In
tert-butyl methyl ether;
at -78 ℃;
for 0.0833333h;
Molecular sieve;
danishefsky's diene;
In
tert-butyl methyl ether;
at -78 - -30 ℃;
for 20h;
With
trifluoroacetic acid;
In
dichloromethane; tert-butyl methyl ether;
at -78 - 20 ℃;
diastereoselective reaction;
DOI:10.1021/ol3007698
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.83 h / -78 °C / Inert atmosphere
2.1: (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / chloroform; N,N-dimethyl-formamide / 72 h
3.1: Jacobsen's catalyst / tert-butyl methyl ether / 0.08 h / -78 °C / Molecular sieve
3.2: 20 h / -78 - -30 °C
3.3: -78 - 20 °C
With
Jacobsen's catalyst; (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; diisobutylaluminium hydride;
In
dichloromethane; tert-butyl methyl ether; chloroform; N,N-dimethyl-formamide; toluene;
3.2: Diels-Alder reaction;
DOI:10.1021/ol3007698
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / benzene / 12 h / Reflux
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.83 h / -78 °C / Inert atmosphere
3.1: (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / chloroform; N,N-dimethyl-formamide / 72 h
4.1: Jacobsen's catalyst / tert-butyl methyl ether / 0.08 h / -78 °C / Molecular sieve
4.2: 20 h / -78 - -30 °C
4.3: -78 - 20 °C
With
Jacobsen's catalyst; (S)-2-tert-butyl-3-methylimidazolidin-4-one trichloroacetic acid salt; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; diisobutylaluminium hydride; triethylamine;
In
dichloromethane; tert-butyl methyl ether; chloroform; N,N-dimethyl-formamide; toluene; benzene;
4.2: Diels-Alder reaction;
DOI:10.1021/ol3007698
