5-nitrobenzofuran

Base Information

• Chemical Name: 5-nitrobenzofuran
• CAS No.: 18761-31-4
• Molecular Formula: C8H5NO3
• Molecular Weight: 163.133
• Hs Code.: 2932999099
• Mol file: 18761-31-4.mol

Synonyms:5-Nitro-[2,3]-benzofuran;5-Nitrobenzofuran;

Chemical Property of 5-nitrobenzofuran

Chemical Property:

• Boiling Point: 273.1 °C at 760 mmHg
• Flash Point: 119 °C
• PSA: 58.96000
• Density: 1.38 g/cm³
• LogP: 2.86420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Nitro-1-benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Nitro-1-benzofuran is a chemical reagent used in the synthesis of internal alkynes. Also used in the preparation of anti-oxidants quinolines.

Technology Process of 5-nitrobenzofuran

There total 17 articles about 5-nitrobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-nitro-2-(prop-1-enyl)-1-(prop-1-enyloxy)benzene (863659-53-4) → 5-nitrobenzofuran (18761-31-4)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 90 ℃; for 3h;

DOI:10.1016/j.tet.2005.05.090

Reference yield: 60.0%

2-fluoro-5-nitro-1-<(trimethylsilyl)ethynyl>benzene (77123-61-6) → 5-nitrobenzofuran (18761-31-4)

Guidance literature:

With sodium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield: 25.3%

2-(2-formyl-4-nitrophenoxy)acetic acid (6965-69-1) → 5-nitrobenzofuran-2-carboxylic acid (10242-12-3) + 5-nitrobenzofuran (18761-31-4)

Guidance literature:

With sodium acetate; acetic anhydride; at 110 ℃; for 3h;

DOI:10.1246/bcsj.56.2762

upstream raw materials:

5-nitrobenzofuran-2-carboxylic acid

ethyl 5-nitrobenzo[d]furan-2-carboxylate

2-(2-formyl-4-nitrophenoxy)acetic acid

2-<2-hydroxy-1-(isopropylthio)ethyl>-4-nitrophenol

Downstream raw materials:

2,3-dihydro-1-benzofuran-5-amine

1-benzofuran-5-amine

Refernces

• 1、 Van Otterlo, Willem A.L.,Morgans, Garreth L.,Madeley, Lee G.,Kuzvidza, Samuel,Moleele, Simon S.,Thornton, Natalie,De Koning, Charles B.. "An isomerization-ring-closing metathesis strategy for the synthesis of substituted benzofurans". . p. 7746 - 7755. Retrieved 2007/10/03.
• 2、 -. "Vanilloid receptor ligands and their use in treatments". . . Retrieved 2008/06/13.