2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene

Base Information

• Chemical Name: 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene
• CAS No.: 351536-13-5
• Molecular Formula: C₁₆H₂₃Cl₃OSi
• Molecular Weight: 365.803
• Mol file: 351536-13-5.mol

Synonyms:2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene

Chemical Property of 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene

There total 2 articles about 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(E)-1,1,1-trichloro-4-phenylbut-3-en-2-ol (96349-58-5) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene (351536-13-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jo010068c

Reference yield:

(E)-3-phenylpropenal (14371-10-9) → 2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene (351536-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / CCl₃CO₂H / dimethylformamide / 20 °C

2: 91 percent / imidazole / dimethylformamide / 20 °C

With 1H-imidazole; trichloroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jo010068c

Reference yield: 88.0%

2-tert-butyldimethylsilyloxy-1,1,1-trichloro-4-phenyl-3-butene (351536-13-5) → (E)-1,1,1-trichloro-4-phenylbut-3-en-2-ol (96349-58-5)

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo010068c

upstream raw materials:

(E)-1,1,1-trichloro-4-phenylbut-3-en-2-ol

tert-butyldimethylsilyl chloride

(E)-3-phenylpropenal

Downstream raw materials:

(E)-1,1,1-trichloro-4-phenylbut-3-en-2-ol

2,2,2-trichloro-1-styrylethyl acetate

[(E)-1,1,1-trichloro-4-phenylbut-3-en-2-yloxy]trimethylsilane

Benzoic acid (E)-3-phenyl-1-trichloromethyl-allyl ester