Chemical Property of ALPHA-APO-OXYTETRACYCLINE
Chemical Property:
- Melting Point:200-204 °C
- Boiling Point:742.4±60.0 °C(Predicted)
- PKA:1.62±0.58(Predicted)
- PSA：170.62000
- Density:1.62±0.1 g/cm3(Predicted)
- LogP:1.25860
- Storage Temp.:Refrigerator, Under Inert Atmosphere
- Solubility.:Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated)
- Purity/Quality:
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98%Min *data from raw suppliers
β-Apo-oxytetracycline *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
63
- Safety Statements:
45-36/37
- MSDS Files:
-
SDS file from LookChem
Useful:
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Description
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.
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Uses
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability. β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
