2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

Base Information

Chemical Name:2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone
CAS No.:1256285-05-8
Molecular Formula:C₂₂H₂₂ClNO
Molecular Weight:351.876
Hs Code.:

Synonyms:2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

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Technology Process of 2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

There total 5 articles about 2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1014623-83-6
6-chloro-1-methyl-2-(4-pentenyl)-1H-indole

: 19832-78-1
1-(4-methylphenyl)prop-2-en-1-one

: 1256285-05-8
2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In 1,2-dichloro-ethane; for 4h; Reflux;
DOI:10.1002/asia.201000315

Reference yield:

: 2689-61-4
(2-oxo-2-p-tolylethyl)triphenylphosphonium bromide

: 1256285-05-8
2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol; water / 1 h / 20 °C

1.2: 20 °C / pH 7 - 8

2.1: dichloromethane / Reflux; Inert atmosphere

3.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 4 h / Reflux

With Hoveyda-Grubbs catalyst second generation; In methanol; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1002/asia.201000315

Reference yield:

: 122-00-9
para-methylacetophenone

: 1256285-05-8
2-(7-chloro-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)-1-p-tolylethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(ll) bromide / chloroform; ethyl acetate / 0.33 h / Reflux; Inert atmosphere

2.1: triethylamine / toluene / 20 °C

3.1: methanol; water / 1 h / 20 °C

3.2: 20 °C / pH 7 - 8

4.1: dichloromethane / Reflux; Inert atmosphere

5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 4 h / Reflux

With Hoveyda-Grubbs catalyst second generation; triethylamine; copper(ll) bromide; In methanol; dichloromethane; chloroform; water; ethyl acetate; 1,2-dichloro-ethane; toluene;
DOI:10.1002/asia.201000315