2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal

Base Information

• Chemical Name: 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal
• CAS No.: 123694-53-1
• Molecular Formula: C₁₆H₂₀O₅S
• Molecular Weight: 324.398

Synonyms:2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal

Chemical Property of 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal

Chemical Property:

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Technology Process of 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal

There total 2 articles about 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + 3-thiophenecarboxaldehyde dimethyl acetal → 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal (123694-53-1)

Guidance literature:

With n-butyllithium; 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, -78 deg C, 1 h;

DOI:10.1021/jo00103a029

Reference yield:

→ 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal (123694-53-1)

Guidance literature:

Reference yield: 74.0%

dimethyl acetylenedicarboxylate (762-42-5) + 2-(α-Hydroxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde dimethyl acetal (123694-53-1) → 4-Hydroxy-5,6-bis(methoxycarbonyl)-7-(3,4-dimethoxyphenyl)benzothiophene (123716-10-9) + 2-(α-Methoxy-3,4-dimethoxybenzyl)thiophene-3-carbaldehyde

Guidance literature:

trifluoroacetic acid; In benzene; for 1h; Heating;

DOI:10.1021/jo00103a029

upstream raw materials:

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

4-Hydroxy-5,6-bis(methoxycarbonyl)-7-(3,4-dimethoxyphenyl)benzothiophene

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