6B-TROPANOL

Base Information

• Chemical Name: 6B-TROPANOL
• CAS No.: 18700-21-5
• Molecular Formula: C₈H₁₅NO
• Molecular Weight: 141.213
• Mol file: 18700-21-5.mol

Synonyms:1bH,5bH-Tropan-6b-ol (8CI); 8-Azabicyclo[3.2.1]octan-6-ol, 8-methyl-, endo-

Chemical Property of 6B-TROPANOL

Chemical Property:

• Vapor Pressure: 0.0355mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 213.8°C at 760 mmHg
• Flash Point: 80.4°C
• PSA: 23.47000
• Density: 1.078g/cm³
• LogP: 0.54180

Purity/Quality:

97% ^*data from raw suppliers

(1R,5S,6S)-rel-8-Methyl-8-azabicyclo[3.2.1]octan-6-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6B-TROPANOL

There total 22 articles about 6B-TROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-nitrobenzoic acid (+/-)-8-methyl-8-azabicyclo[3.2.1]octan-β-yl ester → (+/-)-8-methyl-8-azabicyclo[3.2.1]octan-α-ol (18700-21-5,18700-23-7,126120-91-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1021/jm0490235

Reference yield: 70.0%

N-(benzyloxycarbonyl)-6α,7α-epoxy-8-azabicyclo<3.2.1>octane (169219-73-2) → (+/-)-8-methyl-8-azabicyclo[3.2.1]octan-α-ol (18700-21-5,18700-23-7,126120-91-0)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/0040-4039(95)00836-2

Reference yield: 70.0%

N-(benzyloxycarbonyl)-6β,7β-epoxy-8-azabicyclo<3.2.1>octane (169124-56-5) → (+/-)-8-methyl-8-azabicyclo[3.2.1]octan-β-ol (18700-21-5,18700-23-7,126120-91-0)

Guidance literature:

With diisobutylaluminium hydride; at 25 ℃;

DOI:10.1016/0040-4039(95)00836-2

upstream raw materials:

N-(benzyloxycarbonyl)-6α,7α-epoxy-8-azabicyclo<3.2.1>octane

(+/-)-8-methyl-8-azabicyclo[3.2.1]octan-β-ol

(1R,5R,6S)-6-Hydroxy-8-methyl-8-aza-bicyclo[3.2.1]octan-3-one

cis-4-[(benzyloxycarbonyl)amino]cyclohept-2-enol

Downstream raw materials:

(+/-)-8-methyl-8-azabicyclo[3.2.1]octan-α-ol

Acetic acid (1S,5R,6S,8S)-8-(3-oxo-3-phenyl-propyl)-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Acetic acid (1S,5R,6S,8S)-8-phenethyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Acetic acid (1S,5R,6S,8S)-6-(3,4-dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

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