169124-56-5Relevant academic research and scientific papers
Exo- and Endo-6-Hydroxy- and 6,7-Epoxytropanes; Total Synthesis of Scopine, Pseudoscopine, and Nor- Derivatives
Justice, David E.,Malpass, John R.
, p. 4689 - 4692 (1995)
Novel endo- 6,7-epoxy-8-azabicyclooctane derivatives and the corresponding exo-analogues have been synthesised and show substantially different reactivity; the resistance of the exo-epoxides to ring opening during hydride reduction and catalytic hydrogenolysis is exploited in a total synthesis of scopine, pseudoscopine, and nor- derivatives.
Synthesis of exo- and endo-6,7-epoxytropanes
Justice, David E.,Malpass, John R.
, p. 11963 - 11976 (2007/10/03)
Diastereoisomeric N-protected 2,3-epoxy-4-amino-cycloheptanols are synthesised; cyclisation of derivatives provides a practical route to N-protected exo-(β)-6,7-epoxynortropanes and the first endo-(α-)-6,7-epoxynortropane. Hydride reduction gives the corr
