4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide

Base Information

• Chemical Name: 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide
• CAS No.: 1373516-17-6
• Molecular Formula: C₁₆H₁₂IN₃O₂
• Molecular Weight: 405.195
• Mol file: 1373516-17-6.mol

Synonyms:4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide

Chemical Property of 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide

There total 2 articles about 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-cyanobenzohydrazide (43038-36-4) + 3-iodophenylacetic acid (1878-69-9) → 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide (1373516-17-6)

Guidance literature:

3-iodophenylacetic acid; With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In ISOPROPYLAMIDE; at 20 ℃; for 2h;

4-cyanobenzohydrazide; In ISOPROPYLAMIDE; at 60 ℃; for 2h;

Reference yield:

4-cyanobenzoic acid methyl ester (1129-35-7) → 4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide (1373516-17-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 1 h / 80 °C

2.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / ISOPROPYLAMIDE / 2 h / 20 °C

2.2: 2 h / 60 °C

With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In ethanol; ISOPROPYLAMIDE;

Reference yield: 61.0%

4-cyano-benzoic acid N'-[2-(3-iodo-phenyl)-acetyl]-hydrazide (1373516-17-6) → 4-[5-(3-iodo-benzyl)-[1,3,4]thiadiazol-2-yl]-benzonitrile (1373516-21-2)

Guidance literature:

With tetraphosphorus decasulfide; In 1,4-dioxane; at 20 - 40 ℃; for 1.25h;

upstream raw materials:

4-cyanobenzohydrazide

3-iodophenylacetic acid

4-cyanobenzoic acid methyl ester

Downstream raw materials:

4-[5-(3-iodo-benzyl)-[1,3,4]thiadiazol-2-yl]-benzonitrile