3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

Base Information

Chemical Name:3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester
CAS No.:144562-00-5
Molecular Formula:C₂₈H₃₅NO₄
Molecular Weight:449.59
Hs Code.:

Synonyms:3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

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Chemical Property of 3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

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Technology Process of 3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

There total 5 articles about 3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 94820-24-3
(+)-(1R,2R,3S)-2-(1-n-butyl-2-isobutylcarbonyloxy-3-methoxymethyl-oxybutyl)-4,5-diphenyloxazole

: 144562-00-5
3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

: 94820-25-4
(+)-(1R,2R,3S)-2-(1-n-butyl-2-isobutylcarbonyloxy-3-hydroxybutyl)-4,5-diphenyloxazole

Guidance literature:: With hydrogenchloride; In methanol; at 60 ℃; for 2.5h;
DOI:10.1016/S0040-4020(01)88247-8

Reference yield:

: 20662-96-8
2-n-pentyl-4,5-diphenyloxazole

: 144562-00-5
3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, -78 deg C, 30 min

2: 26 percent / pyridine / 24 h / Ambient temperature

3: 4 percent / BF₃*Et₂O, thiophenol / CH₂Cl₂ / 1.5 h / Ambient temperature

With pyridine; n-butyllithium; boron trifluoride diethyl etherate; thiophenol; In dichloromethane;
DOI:10.1016/S0040-4020(01)88247-8

Reference yield:

: 14224-99-8
2-methyl-4,5-diphenyloxazole

: 144562-00-5
3-Methyl-butyric acid (1S,2R,3R)-3-(4,5-diphenyl-oxazol-2-yl)-2-hydroxy-1-methyl-heptyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, -78 deg C, 1 h

2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, -78 deg C, 30 min

3: 26 percent / pyridine / 24 h / Ambient temperature

4: 4 percent / BF₃*Et₂O, thiophenol / CH₂Cl₂ / 1.5 h / Ambient temperature

With pyridine; n-butyllithium; boron trifluoride diethyl etherate; thiophenol; In dichloromethane;
DOI:10.1016/S0040-4020(01)88247-8