6-Chloroquinolin-2-amine

Base Information

• Chemical Name: 6-Chloroquinolin-2-amine
• CAS No.: 18672-02-1
• Molecular Formula: C9H7ClN2
• Molecular Weight: 179.61
• Hs Code.: 2933499090
• ChEMBL ID: CHEMBL189514
• DSSTox Substance ID: DTXSID80555326
• Nikkaji Number: J82.794K
• Wikidata: Q82436640
• Mol file: 18672-02-1.mol

Synonyms:6-CHLOROQUINOLIN-2-AMINE;18672-02-1;2-AMINO-6-CHLOROQUINOLINE;6-Chloro-2-quinazolinamine;6-CHLORO-2-QUINOLINAMINE;CHEMBL189514;MFCD08235108;6-Chloro-quinolin-2-ylamine;SCHEMBL2130719;DTXSID80555326;QXGSBXTUXCTJII-UHFFFAOYSA-N;AMY36628;BDBM50154589;AKOS013465535;AB43744;AC-14798;CS-11856;SY031686;A4132;CS-0313665;N12853

Chemical Property of 6-Chloroquinolin-2-amine

Chemical Property:

• Melting Point: 146-150 °C
• Boiling Point: 340.5 °C at 760 mmHg
• PKA: 5.83±0.43(Predicted)
• Flash Point: 159.7 °C
• PSA: 38.91000
• Density: 1.363 g/cm³
• LogP: 3.05160
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 178.0297759
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-6-chloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=N2)N)C=C1Cl

Technology Process of 6-Chloroquinolin-2-amine

There total 4 articles about 6-Chloroquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,6-dichloroquinoline (1810-72-6) → 2-amino-6-chloroquinoline (18672-02-1)

Guidance literature:

With acetamide; potassium carbonate; at 200 ℃;

DOI:10.1021/jm049533z

Reference yield:

acetamide (60-35-5) + 2,6-dichloroquinoline (1810-72-6) → 2-amino-6-chloroquinoline (18672-02-1)

Guidance literature:

With potassium carbonate; at 200 ℃; for 4h; Inert atmosphere;

Reference yield:

C9H5ClN2O2 (1334594-87-4) → 2-amino-6-chloroquinoline (18672-02-1)

Guidance literature:

With acetic acid; zinc; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/c2ob25709b

upstream raw materials:

2,6-dichloroquinoline

C₉H₅ClN₂O₂

5-chloro-2-nitrobenzaldehyde

acetamide