4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Base Information

Chemical Name:4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate
CAS No.:1402402-90-7
Molecular Formula:C₂₈H₂₇ClN₄O₆
Molecular Weight:550.999
Hs Code.:

Synonyms:4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

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Chemical Property of 4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

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Technology Process of 4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

There total 5 articles about 4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5070-13-3
bis-(p-nitrophenyl) carbonate

: 1402402-89-4
N,N-di-n-propyl-[2-(6-chloro-2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

: 1402402-90-7
4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.ijpharm.2012.08.023

Reference yield:

: 1072-98-6
5-chloro-2-pyridylamine

: 1402402-90-7
4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: butan-1-ol / Inert atmosphere; Reflux

2: water; sodium hydroxide / butan-1-ol / 50 °C / Inert atmosphere

3: hydrogen bromide / Inert atmosphere; Reflux

4: triethylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

With water; hydrogen bromide; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.ijpharm.2012.08.023

Reference yield:

: 1402402-91-8
C₂₀H₂₁ClN₂O₃

: 1402402-90-7
4-(6-chloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-nitrophenyl carbonate

Guidance literature:: Multi-step reaction with 4 steps

1: water; sodium hydroxide / butan-1-ol / 50 °C / Inert atmosphere

2: hydrogen bromide / Inert atmosphere; Reflux

3: triethylamine; 1,1'-carbonyldiimidazole / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: triethylamine / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere

With water; hydrogen bromide; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.ijpharm.2012.08.023