4-Chloro-6-methyl-2-phenylquinoline

Base Information

• Chemical Name: 4-Chloro-6-methyl-2-phenylquinoline
• CAS No.: 18618-02-5
• Molecular Formula: C₁₆H₁₂ClN
• Molecular Weight: 253.731
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID50427420
• Wikidata: Q82240073
• Mol file: 18618-02-5.mol

Synonyms:4-Chloro-6-methyl-2-phenylquinoline;18618-02-5;Oprea1_099699;SCHEMBL10865512;DTXSID50427420;PFLXBAREWKKMOZ-UHFFFAOYSA-N;MFCD09750378;AKOS002670380;SB70490;4-CHLORO-6-METHYL-8-PHENYLQUINOLINE;?4-CHLORO-6-METHYL-2-PHENYLQUINOLINE

Chemical Property of 4-Chloro-6-methyl-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 4.55E-06mmHg at 25°C
• Refractive Index: 1.647
• Boiling Point: 394.3°Cat760mmHg
• Flash Point: 224.4°C
• PSA: 12.89000
• Density: 1.206g/cm³
• LogP: 4.86360
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 253.0658271
• Heavy Atom Count: 18
• Complexity: 274

Purity/Quality:

98%Min ^*data from raw suppliers

4-Chloro-6-methyl-2-phenylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N=C(C=C2Cl)C3=CC=CC=C3

Technology Process of 4-Chloro-6-methyl-2-phenylquinoline

There total 8 articles about 4-Chloro-6-methyl-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) + p-toluidine (106-49-0,12221-03-3) → 8-chloro-5-methyl-2-phenylquinoline (18618-02-5)

Guidance literature:

Reference yield:

2,4-dichloro-6-methyl-quinoline (102878-18-2) + phenylboronic acid (98-80-6) → 8-chloro-5-methyl-2-phenylquinoline (18618-02-5) + C16H12ClN (1094428-49-5) + 2,4-diphenyl-6-methylquinoline (73402-92-3)

Guidance literature:

With C₅₆H₅₂N₁₂O₁₂Pd₄S₄; potassium carbonate; In ethanol; water; at 80 ℃; for 18h;

DOI:10.1021/acs.inorgchem.9b00794

Reference yield:

6-methyl-2-phenyl-quinolin-4-ol (1148-49-8) → 8-chloro-5-methyl-2-phenylquinoline (18618-02-5)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

6-methyl-2-phenyl-quinolin-4-ol

ethyl 3-oxo-3-phenylpropionate

p-toluidine

2,4-dichloro-6-methyl-quinoline

Downstream raw materials:

6-methyl-2-phenyl-[4]quinolylamine

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