101803-29-6

Basic information

• Product Name: (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
• Synonyms: (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine
• CAS NO: 101803-29-6
• Molecular Weight: 324.29
• Mol File: 101803-29-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine(101803-29-6)
• EPA Substance Registry System: (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine(101803-29-6)

Safety Data

• Hazardous Substances Data: 101803-29-6(Hazardous Substances Data)

Upstream product

• 4457-32-3 4-nitrobenzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 67-56-1 methanol 
• 96034-57-0 (2S,4R)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid 

Downstream Products

• 117811-69-5 (2S,4R)-4-t-butyldimethylsilyloxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 491878-06-9 (2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester 
• 352307-06-3 4-nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-[6-[(3S,5S)-5-methoxycarbonyl-1-(4-nitrobenzyloxy-carbonyl)pyrrolidin-3-yl]-7-methylthioimidazo[5,1-b]thiazolium-2-yl]-1-carbapen-2-em-3-carboxylate chloride 
• 127767-63-9 4-Nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[(2S,4S)-2-[2-{N-methyl-N-(4-nitrobenzyloxycarbonyl)amino}ethyloxymethyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidin-4-yl]thio-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 199998-99-7 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-3-{(3S,5S)-1-(4-nitro-benzyloxycarbonyl)-5-[2-(4-nitro-benzyloxycarbonylamino)-ethoxymethyl]-pyrrolidin-3-ylsulfanyl}-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 199998-75-9 (4R,5S,6S)-3-[(3S,5S)-5-Allyloxycarbonylmethoxymethyl-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 199998-97-5 (4R,5S,6S)-3-[(3S,5S)-5-(1-Carbamoyl-1-methyl-ethoxymethyl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 127767-60-6 4-Nitrobenzyl (4R,5S,6S)-3-[(2S,4S)-2-(dimethylcarbamoyl)methyloxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidin-4-yl]thio-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 
• 127767-61-7 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-4-methyl-3-[(3S,5S)-5-methylcarbamoylmethoxymethyl-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 127767-62-8 (4R,5S,6S)-3-[(3S,5S)-5-(2-Dimethylamino-ethoxymethyl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 199998-96-4 (4R,5S,6S)-3-[(3S,5S)-5-Carbamoylmethoxymethyl-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 199998-98-6 (4R,5S,6S)-3-[(3S,5S)-5-(2-Hydroxy-ethoxymethyl)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 127767-91-3 (2S,4R)-4-methanesulfonyloxy-2-[2-{N-methyl-N-(4-nitrobenzyloxycarbonyl)amino}ethyloxymethyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 199998-80-6 (2S,4R)-4-Methanesulfonyloxy-2-[2-(4-nitro-benzyloxycarbonylamino)-ethoxymethyl]-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

Synthesis and?antibacterial activities of?new 1β-methylcarbapenems having aminopyrimidinylthioether moiety

The synthesis of new 1β-methylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I).

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The synthesis and biological activity of a series of new 1β- methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.

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