104795-10-0

Upstream product

• 4457-32-3 4-nitrobenzyl chloroformate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 51-35-4 4R-4-hydroxyproline 
• 101803-29-6 (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 117811-69-5 (2S,4R)-4-t-butyldimethylsilyloxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Downstream Products

• 127812-53-7 (2S,4R)-4-tert-butyldimethylsilyloxy-2-methanesulfonyloxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 137049-21-9 (2S,4R)-2-formyl-4-tert-butyldimethylsilyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 104773-45-7 (2S,4R)-4-tert-butyldimethylsilyloxy-2-iodomethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127812-56-0 (2S,4R)-4-hydroxy-2-(imidazol-1-yl)methyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127812-74-2 (2S,4S)-2-Imidazol-1-ylmethyl-4-mercapto-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 127812-58-2 (2S,4R)-2-(imidazol-1-yl)methyl-4-methanesulfonyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127812-70-8 (2S,4S)-4-acetylthio-2-(imidazol-1-yl)methyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127812-54-8 (2S,4R)-4-tert-butyldimethylsilyloxy-2-(imidazol-1-yl)methyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127812-37-7 (4R,5S,6S)-6-((R)-1-Hydroxy-ethyl)-3-[(3S,5S)-5-imidazol-1-ylmethyl-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 117811-73-1 (2S,4R)-2-Carboxymethoxymethyl-4-hydroxy-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 127768-01-8 (2S,4S)-2-[2-(Dimethylamino)ethyloxymethyl]-4-mercapto-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 127768-00-7 (2S,4S)-4-Mercapto-2-(methylcarbamoyl)methyloxymethyl-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 199998-90-8 (2S,4S)-4-Acetylsulfanyl-2-(2-hydroxy-ethoxymethyl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 117811-56-0 (2S,4R)-2-(1-carboxy-1-methylethyl)oxymethyl-4-hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety

The synthesis and biological activity of a series of new 1β- methylcarbapenems 1a-g containing 5'-isoxazolopyrrolidin-3'-ylthio derivatives as C-2 side chain are described. Most compounds exhibited potent and well-balanced antibacterial activity as well as high stability to DHP-I comparable to that of meropenem. 1e and 1c showed the best combination of antibacterial activity and stability to DHP-I, respectively.

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems - I. 2-alkoxymethyl derivatives

The synthesis and in vitro antibacterial activity of a novel series of 2-alkoxymethyl-4-pyrrolidinylthio-1β-methyl carbapenems are described. As a result of these studies, we discovered that FR27743 (19j) containing a novel 2-fluoroethoxymethyl substituen

2-(2-cyclopropylpyrrolidin-4-ylthio)carbapenhem derivatives

A compound of the formula: STR1 wherein R1 is a hydrogen atom or a methyl group, each of R2 and R3 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R2 and R3 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group and a morpholino group, A is a carbonyl group or a single bond, and n is an integer of from 0 to 3; or a pharmaceutically acceptable salt or ester thereof.