({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

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Chemical Name:({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester
CAS No.:202811-34-5
Molecular Formula:C₃₁H₃₅N₃O₅
Molecular Weight:529.636
Hs Code.:

Synonyms:({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

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Chemical Property of ({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

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Technology Process of ({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

There total 3 articles about ({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 202811-15-2
N-(2-(2-amino-phenyl)ethyl)-N-methylcarbamic acid tert-butyl ester

: 202811-34-5
({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

Guidance literature:: N-(fluoren-9-ylmethoxycarbonyl)glycine; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h;

N-(2-(2-amino-phenyl)ethyl)-N-methylcarbamic acid tert-butyl ester; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 202811-34-5
({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 38 percent / aq. NaOH / tetrahydrofuran / 16 h / 20 °C

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 96 percent / CH₂Cl₂ / 16 h / 0 - 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Addition / 2.2: Condensation;
DOI:10.1016/S0223-5234(00)00160-4

Reference yield:

: 22908-49-2
2-(2-methylamino-ethyl)-phenylamine

: 202811-34-5
({2-[2-(N-(tert-butoxycarbonyl)-N-methylamino)ethyl]phenylcarbamoyl}methyl)carbamic acid ((9-fluorenyl)methyl)-ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 38 percent / aq. NaOH / tetrahydrofuran / 16 h / 20 °C

2.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 96 percent / CH₂Cl₂ / 16 h / 0 - 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; 1.1: Substitution / 2.1: Addition / 2.2: Condensation;
DOI:10.1016/S0223-5234(00)00160-4