Technology Process of 1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-3-oxonon-1(E)-en-1-yl)cyclopropane
There total 11 articles about 1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-3-oxonon-1(E)-en-1-yl)cyclopropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 93 percent / potassium carbonate / methanol; H2O / 3 h
2: 90 percent / lithium diisopropylamide, HMPA / tetrahydrofuran / -78 deg C -> room temperature, overnight
3: 1.) DIBAL-H, 2.) 6percent aq. sulfuric acid / 1.) toluene, hexane, 0 deg C, 3 h, 2.) room temperature, 1 h
4: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
5: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; methanol; water;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2.) HMPA / 1.) THF, -78 deg C, 20 min, 2.) reflux, overnight
2: 63 percent / 0.5 M hydrochloric acid / tetrahydrofuran / 24 h
3: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
4: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
With
pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / lithium diisopropylamide, HMPA / tetrahydrofuran / -78 deg C -> room temperature, overnight
2: 1.) DIBAL-H, 2.) 6percent aq. sulfuric acid / 1.) toluene, hexane, 0 deg C, 3 h, 2.) room temperature, 1 h
3: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
4: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; diisobutylaluminium hydride; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran;
DOI:10.1021/ja00547a015
