1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

Base Information

Chemical Name:1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane
CAS No.:76042-20-1
Molecular Formula:C₂₇H₃₆O₅S
Molecular Weight:472.646
Hs Code.:

Synonyms:1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

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Chemical Property of 1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

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Technology Process of 1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

There total 9 articles about 1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 76042-16-5
1-((2,6-dimethoxyphenyl)thio)cyclopropane-1-carboxaldehyde

: 76042-17-6
3-(benzyloxy)octan-2-one

: 76042-20-1
1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/ja00547a015

Reference yield:

: 26163-11-1
2,6-dimethoxybenzenethiol

: 76042-20-1
1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / potassium carbonate / methanol; H₂O / 3 h

2: 90 percent / lithium diisopropylamide, HMPA / tetrahydrofuran / -78 deg C -> room temperature, overnight

3: 1.) DIBAL-H, 2.) 6percent aq. sulfuric acid / 1.) toluene, hexane, 0 deg C, 3 h, 2.) room temperature, 1 h

4: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sulfuric acid; diisobutylaluminium hydride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;
DOI:10.1021/ja00547a015

Reference yield:

: 100-39-0
benzyl bromide

: 76042-20-1
1-((2,6-dimethoxyphenyl)thio)-1-(4-(benzyloxy)-1-hydroxy-3-oxononan-1-yl)cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) HMPA / 1.) THF, -78 deg C, 20 min, 2.) reflux, overnight

2: 63 percent / 0.5 M hydrochloric acid / tetrahydrofuran / 24 h

3: 70 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ja00547a015