methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate

Base Information

• Chemical Name: methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate
• CAS No.: 724461-48-7
• Molecular Formula: C₂₄H₃₅O₆PSi
• Molecular Weight: 478.598
• Mol file: 724461-48-7.mol

Synonyms:methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate

Chemical Property of methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate

There total 2 articles about methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

trimethyl phosphonoacetate (5927-18-4) + 1-(t-butyldiphenylsilyloxy)-3-iodopropane (114671-83-9) → methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate (724461-48-7)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 2.66667h;

DOI:10.1016/j.tetasy.2004.04.004

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate (724461-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / imidazole / CH₂Cl₂ / 20 °C

2: 71 percent / sodium hydride / dimethylsulfoxide / 2.67 h / 20 °C

With 1H-imidazole; sodium hydride; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.tetasy.2004.04.004

Reference yield: 71.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl 5-[(tert-butyldiphenylsilyl)oxy]-2-(dimethoxyphosphoryl)pentanoate (724461-48-7) → 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-acrylic acid methyl ester (724461-52-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 6h; Heating;

DOI:10.1016/j.tetasy.2004.04.004

upstream raw materials:

trimethyl phosphonoacetate

1-(t-butyldiphenylsilyloxy)-3-iodopropane

tert-butylchlorodiphenylsilane

Downstream raw materials:

2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-acrylic acid methyl ester

2-{3-[(tert-butyldiphenylsilyl)oxy]propyl}prop-2-en-1-ol

5-(tert-butyldiphenylsilanyloxy)-2-methylene-pentanal

2-{3-[(tert-butyldiphenylsilyl)oxy]propyl}-1-(furan-3-yl)prop-2-en-1-ol