(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

Base Information

Chemical Name:(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one
CAS No.:137959-85-4
Molecular Formula:C₂₄H₃₀N₂O₂
Molecular Weight:378.514
Hs Code.:

Synonyms:(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

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Chemical Property of (2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

Chemical Property:

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Technology Process of (2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

There total 5 articles about (2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138052-34-3
(2R,5R)-1-Benzoyl-2-tert-butyl-3,5-dimethylimidazolidin-4-one

: 585-71-7,38661-81-3
(1-bromoethyl)benzne

: 137959-84-3
(2R,5R,5αR)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

: 137959-85-4
(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)93551-2

Reference yield:

: 98-88-4
benzoyl chloride

: 137959-85-4
(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine / CH₂Cl₂

2: LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 45 min, 2.) -78 deg C, 60 h

With N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo00086a033

Reference yield:

: 630-19-3
pivalaldehyde

: 137959-85-4
(2R,5R,5αS)-1-Benzoyl-2-tert-butyl-3,5-dimethyl-5-(α-methylbenzyl)imidazolidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: diisopropylethylamine, MgSO₄ / CH₂Cl₂ / 24 h

2: CH₃COCl / ethanol / 1 h / Ambient temperature

3: diisopropylethylamine / CH₂Cl₂

4: LDA / tetrahydrofuran; hexane / 1.) -78 deg C, 45 min, 2.) -78 deg C, 60 h

With magnesium sulfate; N-ethyl-N,N-diisopropylamine; acetyl chloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/jo00086a033