(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

Base Information

Chemical Name:(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol
CAS No.:221649-19-0
Molecular Formula:C₁₇H₂₈ClNO₂Si
Molecular Weight:341.953
Hs Code.:

Synonyms:(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

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Chemical Property of (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

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Technology Process of (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

There total 5 articles about (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 221649-15-6
(2S,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-one

: 221649-19-0
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

: (1S,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at -98 - -60 ℃; for 2.5h;
DOI:10.1002/anie.200501745

Reference yield:

: 868528-86-3
bis(6-chloropyridin-3-yl)iodonium chloride

: 221649-19-0
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: (R,R)-bis(α-methylbenzyl)amine hydrochloride; BuLi / tetrahydrofuran; dimethylformamide; hexane / 4 h / -45 °C

2: 84 percent / NaBH₄ / methanol / 2.5 h / -98 - -60 °C

With sodium tetrahydroborate; n-butyllithium; (R,R)-(+)-bis[alpha-methylbenzyl]amine hydrochloride; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200501745

Reference yield:

: 53939-30-3
5-bromo-2-chloropyridine

: 221649-19-0
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / ClCH=CHICl₂; BuLi / diethyl ether; hexane / 4 h / -78 - 20 °C

2: (R,R)-bis(α-methylbenzyl)amine hydrochloride; BuLi / tetrahydrofuran; dimethylformamide; hexane / 4 h / -45 °C

3: 84 percent / NaBH₄ / methanol / 2.5 h / -98 - -60 °C

With sodium tetrahydroborate; n-butyllithium; 1-chloro-2-(dichloro-λ³-iodanyl)-ethene; (R,R)-(+)-bis[alpha-methylbenzyl]amine hydrochloride; In tetrahydrofuran; methanol; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1002/anie.200501745