(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

Base Information

Chemical Name:(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane
CAS No.:334700-58-2
Molecular Formula:C₁₈H₃₀ClNO₄SSi
Molecular Weight:420.045
Hs Code.:

Synonyms:(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

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Chemical Property of (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

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Technology Process of (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

There total 1 articles about (1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 221649-19-0
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)cyclohexan-1-ol

: 334700-58-2
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1039/b002980g

Reference yield: 88.0%

: 334700-58-2
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

: 221649-23-6
(1S,3R,4R)-3-(2-Chloro-5-pyridyl)-4-[(methylsulfonyl)oxy]cyclohexan-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1039/b002980g

Reference yield:

: 334700-58-2
(1R,2R,4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

: (1R,2R,4R)-4-Azido-2-(2-chloro-5-pyridyl)-1-[(methylsulfonyl)oxy]cyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Bu₄NF / tetrahydrofuran / 24 h / 20 °C

2: 94 percent / HN₃; DEAD; PPh₃ / tetrahydrofuran; benzene / 20 °C

With tris-(2-chloro-ethyl)-amine; tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; benzene; 2: Mitsunobu azide reaction;
DOI:10.1039/b002980g