4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

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Chemical Name:4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide
CAS No.:1470189-89-9
Molecular Formula:C₂₂H₂₃N₅O₅S
Molecular Weight:469.521
Hs Code.:

Synonyms:4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

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Chemical Property of 4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

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Technology Process of 4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

There total 6 articles about 4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1470189-67-3
4-(3-methyl-5-(piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

: 122-04-3
4-nitro-benzoyl chloride

: 1470189-89-9
4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

Guidance literature:: 4-(3-methyl-5-(piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide; With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.333333h; Inert atmosphere;

4-nitro-benzoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1007/s00044-013-0817-8

Reference yield:

: 498-94-2
isonipecotic acid

: 1470189-89-9
4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4.1: ethanol / 20 h / 20 °C / Reflux; Inert atmosphere

5.1: hydrogenchloride / ethanol; water / 4 h / 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

6.2: 3 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Claisen Condensation;
DOI:10.1007/s00044-013-0817-8

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1470189-89-9
4-(3-methyl-5-(1-(4-nitrobenzoyl)piperidin-4-yl)-1H-pyrazol-1-yl)benzenesulphonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

3.1: ethanol / 20 h / 20 °C / Reflux; Inert atmosphere

4.1: hydrogenchloride / ethanol; water / 4 h / 20 °C / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Claisen Condensation;
DOI:10.1007/s00044-013-0817-8