OlMesartan MedoxoMil Ethyl Methyl Analog

Base Information

Chemical Name:OlMesartan MedoxoMil Ethyl Methyl Analog
CAS No.:1378863-74-1
Molecular Formula:C₃₀H₃₂N₆O₆
Molecular Weight:572.621
Hs Code.:
Mol file:1378863-74-1.mol

Synonyms:(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylate

Suppliers and Price of OlMesartan MedoxoMil Ethyl Methyl Analog

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EthylOlmesartanMedoxomil
100mg
$ 1190.00

Medical Isotopes, Inc.
EthylOlmesartanMedoxomil
10 mg
$ 650.00

Total 7 raw suppliers

Chemical Property of OlMesartan MedoxoMil Ethyl Methyl Analog

Chemical Property:

Melting Point:>167°C (Subl.)
Boiling Point:808.7±75.0 °C(Predicted)
PKA:4.15±0.10(Predicted)
Density:1.36±0.1 g/cm3(Predicted)
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

> 95% ^*data from raw suppliers

EthylOlmesartanMedoxomil ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses OlMesartan MedoxoMil Ethyl Methyl Analog is an impurity of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist. Used as an anti-hypertensive. Ethyl Olmesartan Medoxomil is an impurity of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist. Used as an anti-hypertensive.

Technology Process of OlMesartan MedoxoMil Ethyl Methyl Analog

There total 3 articles about OlMesartan MedoxoMil Ethyl Methyl Analog which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1378863-72-9
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate

: 1378863-74-1
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylate

Guidance literature:: With water; acetic acid; at 50 ℃; for 4h;

Reference yield:

: 144689-94-1
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

: 1378863-74-1
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2.33 h / 25 °C / Cooling

2.1: potassium carbonate / acetone / 11 h / Reflux

3.1: potassium hydroxide; water / tetrahydrofuran / 48 h / 25 °C

3.2: 24 h / 40 °C

4.1: water; acetic acid / 4 h / 50 °C

With water; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; acetone;

Reference yield:

: 172875-53-5
ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate

: 1378863-74-1
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 11 h / Reflux

2.1: potassium hydroxide; water / tetrahydrofuran / 48 h / 25 °C

2.2: 24 h / 40 °C

3.1: water; acetic acid / 4 h / 50 °C

With water; potassium carbonate; acetic acid; potassium hydroxide; In tetrahydrofuran; acetone;