172875-53-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(1-Hydroxy-1-methylpropyl)-2-propyl-1H-Imidazole-5-carboxylic acidethylester is used as an intermediate in the synthesis of Ethyl Olmesartan Medoxomil (E925335), which is an angiotensin II receptor antagonist. It plays a crucial role in the development of anti-hypertensive medications, helping to regulate blood pressure and improve the quality of life for patients suffering from hypertension.

Upstream product

• 676-58-4 methylmagnesium chloride 
• 2386-64-3 ethylmagnesium chloride 
• 144689-94-1 diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate 
• 51802-42-7 2-propylimidazole-4,5-dicarbonitrile 
• 1025972-83-1 4-acetyl-2-propylimidazole-5-carboxylic acid 
• 144690-06-2 4-acetyl-2-propylimidazole-5-carbonitrile 
• 925-90-6 ethylmagnesium bromide 
• 144690-07-3 ethyl 4-acetyl-2-propylimidazole-5-carboxylate 

Downstream Products

• 172875-55-7 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-propyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 1378863-69-4 ethyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate 
• 1378863-72-9 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate 
• 1378863-74-1 (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylpropyl)-2-propyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole-5-carboxylate 
• 172875-77-3 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-propyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

(5-METHYL-2-OXO-1,3-DIOXOL-4-YLMETHYL)-4-(1-HYDROXY-1-METHYL-PROPYL)-2-PROPYL-1-[2'- (1H-TETRAZOL-5-YL)BIPHENYL-4-YL-METHYL]IMIDAZOLE-5-CARBOXYLATE AS AN IMPURITY OF OLMESARTAN MEDOXOMIL AND A METHOD OF ITS PREPARATION

The compound of formula VI and a method of its preparation, and intermediates of its preparation. Use of these intermediates as standards in analysis of the angiotensin II antagonist olmesartan medoxomil of formula I and of intermediates of its production

Nonpeptide angiotensin II receptor antagonists: Synthesis, biological activities, and structure - Activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds

A series of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds were prepared and evaluated for their antagonistic activities to the angiotensin II (AII) receptor. Among them, the 4-(1-hydroxyalkyl)-imidazole derivatives had strong binding affinity to the AII receptor and potently inhibited the AII-induced pressor response by intravenous administration. Various esters of these acids showed potent and long-lasting antagonistic activity by oral administration. The most promising compounds were (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (CS-866) and (pivaloyloxy)-methyl esters of 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[(2′-1H-tetrazol-5-ylbiphenyl-4-yl) -methyl]imidazole-5-carboxylic acid (26c). A study involving stereochemical comparison of 26c with the acetylated C-terminal pentapeptide of AII was also undertaken.