Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Base Information

Chemical Name:Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
CAS No.:172875-53-5
Molecular Formula:C13H22N2O3
Molecular Weight:254.33
Hs Code.:2933290090
DSSTox Substance ID:DTXSID90444797
Mol file:172875-53-5.mol

Synonyms:172875-53-5;Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate;Ethyl 5-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-4-carboxylate;SCHEMBL6857533;DTXSID90444797;UDEWGNFXYCGRJV-UHFFFAOYSA-N;FT-0733703;J-520917;Ethyl4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Suppliers and Price of Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4-(2-Hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
50mg
$ 225.00

Crysdot
Ethyl4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 95+%
5g
$ 823.00

Chemenu
ethyl4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 95%
5g
$ 777.00

American Custom Chemicals Corporation
ETHYL-4-(2-HYDROXYBUTAN-2-YL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLATE 95.00%
5MG
$ 504.37

Acrotein
Ethyl4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 97%
0.25g
$ 183.33

Total 27 raw suppliers

Chemical Property of Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

Chemical Property:

Boiling Point:464.9±35.0 °C(Predicted)
PKA:12.97±0.10(Predicted)
PSA：75.21000
Density:1.111±0.06 g/cm3(Predicted)
LogP:2.15640
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:254.16304257
Heavy Atom Count:18
Complexity:285

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl4-(2-Hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1=NC(=C(N1)C(C)(CC)O)C(=O)OCC
Uses Ethyl 4-(2-Hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate is used in the synthesis of Ethyl Olmesartan Medoxomil (E925335), which is an angiotensin II receptor antagonist. Used as an anti-hypertensive.

Technology Process of Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

There total 5 articles about Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 925-90-6
ethylmagnesium bromide

: 144690-07-3
ethyl 4-acetyl-2-propylimidazole-5-carboxylate

: 172875-53-5
ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate

Guidance literature:: In tetrahydrofuran; at -40 ℃; for 2.5h;
DOI:10.1021/jm950450f

Reference yield:

: 676-58-4
methylmagnesium chloride

: 2386-64-3
ethylmagnesium chloride

: 144689-94-1
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate

: 172875-53-5
ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate

Guidance literature:: In tetrahydrofuran; at 25 ℃; for 2.33333h; Cooling;

Reference yield:

: 144690-06-2
4-acetyl-2-propylimidazole-5-carbonitrile

: 172875-53-5
ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 6N aq. HCl / 8 h / Heating

2: HCl / 16 h / Ambient temperature

3: 69 percent / tetrahydrofuran / 2.5 h / -40 °C

With hydrogenchloride; In tetrahydrofuran;
DOI:10.1021/jm950450f