[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Base Information

Chemical Name:[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid
CAS No.:1257394-73-2
Molecular Formula:C₂₈H₂₄F₇NO₂
Molecular Weight:539.493
Hs Code.:

Synonyms:[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

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Chemical Property of [6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

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Technology Process of [6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

There total 8 articles about [6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257394-73-2
[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 40 °C / Inert atmosphere

1.2: 20 °C / Reflux; Inert atmosphere

2.1: 4-methyl-1,2,3-trifluorobenzene / 0.17 h / 120 °C / Microwave irradiation; Inert atmosphere

3.1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; magnesium chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 2.1: Mannich reaction / 4.1: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1257394-73-2
[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-1,2,3-trifluorobenzene / 0.17 h / 120 °C / Microwave irradiation; Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

4: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 4-methyl-1,2,3-trifluorobenzene; 1: Mannich reaction / 3: Suzuki coupling;
DOI:10.1021/ml200175q

Reference yield:

: 1257397-68-4
methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

: 1257394-73-2
[6-{(4-fluorophenyl)[4-(trifluoromethyl)piperidin-1-yl]methyl}-4'-(trifluoromethyl)biphenyl-3-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / Inert atmosphere; Microwave irradiation; Heating

3: water; sodium hydroxide / tetrahydrofuran; methanol / Microwave irradiation; Inert atmosphere; Heating

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1021/ml200175q