methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

Base Information

Chemical Name:methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate
CAS No.:1257397-68-4
Molecular Formula:C₂₂H₂₃F₄NO₃
Molecular Weight:425.423
Hs Code.:

Synonyms:methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

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Technology Process of methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

There total 2 articles about methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 657-36-3
4-Trifluormethyl-piperidin

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1765-93-1
4-fluoroboronic acid

: 1257397-68-4
methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

Guidance literature:: In 4-methyl-1,2,3-trifluorobenzene; at 120 ℃; for 0.166667h; microwave irradiation;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257397-68-4
methyl 2-(4-((4-fluorophenyl)(4-(trifluoromethyl)piperidin-1-yl)methyl)-3-hydroxyphenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 40 °C / Inert atmosphere

1.2: 20 °C / Reflux; Inert atmosphere

2.1: 4-methyl-1,2,3-trifluorobenzene / 0.17 h / 120 °C / Microwave irradiation; Inert atmosphere

With triethylamine; magnesium chloride; In acetonitrile; 4-methyl-1,2,3-trifluorobenzene; 2.1: Mannich reaction;
DOI:10.1021/ml200175q