Technology Process of (2S,4Z)-N-methoxy-2-(4-methoxybenzyloxy)-N-methyl-4-heptenamide
There total 3 articles about (2S,4Z)-N-methoxy-2-(4-methoxybenzyloxy)-N-methyl-4-heptenamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; dicyclohexyl-carbodiimide;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.01.005
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron trifluoride diethyl etherate; sodium iodide / acetonitrile / 1.25 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 3 h / -78 °C / Inert atmosphere
3.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h / 0 °C
3.2: pH 2
4.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
dmap; lithium hydroxide monohydrate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide; sodium iodide;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
2.1: Evans asymmetric alkylation / 2.2: Evans asymmetric alkylation;
DOI:10.1016/j.tet.2011.01.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
1.2: 3 h / -78 °C / Inert atmosphere
2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 1.5 h / 0 °C
2.2: pH 2
3.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
dmap; lithium hydroxide monohydrate; dihydrogen peroxide; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; water;
1.1: Evans asymmetric alkylation / 1.2: Evans asymmetric alkylation;
DOI:10.1016/j.tet.2011.01.005
