tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

Base Information

Chemical Name:tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate
CAS No.:247033-90-5
Molecular Formula:C₃₉H₄₈N₆O₇
Molecular Weight:712.846
Hs Code.:

Synonyms:tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

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Chemical Property of tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

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Technology Process of tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

There total 8 articles about tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 247033-88-1
3-{4-[4-(1H-benzoimidazol-2-ylamino)-piperidin-1-yl]-benzoylamino}-2-benzyloxycarbonylamino-propionic acid tert-butyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 247033-90-5
tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2005.10.061

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 144-55-8
sodium hydrogencarbonate

: 247033-90-5
tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 247035-03-6
4-{4-(1H-benzimidazol-2-ylamino)piperidin-1-yl}benzoic acid

: 247033-90-5
tert-butyl (2S)-benzyloxycarbonylamino-3-[4-[4-{(1-tert-butoxycarbonyl-1H-benzimidazol-2-yl)amino}piperidin-1-yl]benzoylamino]propionate

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / 1-hydroxybenzotriazole hydrate; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 13 h

2: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 20 °C

With 4-methyl-morpholine; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.061