(E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde

Base Information

• Chemical Name: (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde
• CAS No.: 1329669-94-4
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.297
• Mol file: 1329669-94-4.mol

Synonyms:(E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde

Chemical Property of (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde

There total 4 articles about (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C21H24O3 (1329670-14-5) → (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde (1329669-94-4)

Guidance literature:

With FeCl₃*SiO₂; In acetone; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0030-1260031

Reference yield: 55.0%

2-(diethoxymethyl)benzaldehyde (103890-70-6) + 1-benzoylethylidenetriphenylphosphorane (1450-07-3) → (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde (1329669-94-4)

Guidance literature:

In ethanol; water; at 0 - 80 ℃; for 48h;

DOI:10.1039/c3ob42546k

Reference yield:

2-bromobenzaldehyde diethyl acetal (35822-58-3) → (E)-2-(2-methyl-3-oxo-3-phenylprop-1-en-1-yl)benzaldehyde (1329669-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 0 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol; water / 0.33 h / 0 - 78 °C / Inert atmosphere

3.1: FeCl₃*SiO₂ / acetone / 2 h / 20 °C / Inert atmosphere

With n-butyllithium; FeCl₃*SiO₂; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; water; acetone;

DOI:10.1055/s-0030-1260031

upstream raw materials:

C₂₁H₂₄O₃

2-(diethoxymethyl)benzaldehyde

2-bromobenzaldehyde diethyl acetal

1-benzoylethylidenetriphenylphosphorane

Refernces

• 1、 Sanchez-Larios, Eduardo,Holmes, Janice M.,Daschner, Crystal L.,Gravel, Michel. "Synthesis of spiro bis-indanes via domino Stetter-aldol-Michael and Stetter-aldol-aldol reactions: Scope and limitations". supporting information; experimental part. p. 1896 - 1904. Retrieved 2011/08/07.