Benzimidazole, 1-(ethoxymethyl)- (8CI)

Base Information

• Chemical Name: Benzimidazole, 1-(ethoxymethyl)- (8CI)
• CAS No.: 18250-01-6
• Molecular Formula: C10H12 N2 O
• Molecular Weight: 176.218
• Hs Code.: 2933990090
• Mol file: 18250-01-6.mol

Synonyms:Benzimidazole,1-(ethoxymethyl)- (8CI)

Chemical Property of Benzimidazole, 1-(ethoxymethyl)- (8CI)

Chemical Property:

• PSA: 27.05000
• LogP: 2.03030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzimidazole, 1-(ethoxymethyl)- (8CI)

There total 2 articles about Benzimidazole, 1-(ethoxymethyl)- (8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethanol (64-17-5) + 1,2-diamino-benzene (95-54-5) → benzoimidazole (51-17-2,79351-71-6) + 1-(ethoxymethyl)-1H-benzo[d]imidazole (18250-01-6)

Guidance literature:

With indium(III) oxide; at 60 ℃; for 2h; Reagent/catalyst; Temperature; Time; Sealed tube;

DOI:10.1016/j.tetlet.2020.152177

Reference yield: 49.0%

ethanol (64-17-5) + N1,N2-bis((1H-benzotriazol-1-yl)methyl)-benzene-1,2-diamine (1206484-89-0) → 1-Methylbenzimidazole (1632-83-3) + 1-(ethoxymethyl)-1H-benzo[d]imidazole (18250-01-6)

Guidance literature:

With oxygen; for 34h; Reflux;

DOI:10.1016/j.tetlet.2009.10.094

Reference yield:

1-(ethoxymethyl)-1H-benzo[d]imidazole (18250-01-6) → C29H38N6Zr

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium; zinc(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; triphenylphosphine / tetrahydrofuran / 96 h / Reflux

2.1: hydrogenchloride / water / 12 h / 85 °C

3.1: formic acid / methanol / 12 h / 20 °C

3.2: 3 h / 50 °C

4.1: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; formic acid; triphenylphosphine; zinc(II) chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; methanol; water;

DOI:10.1002/cctc.201800077

upstream raw materials:

ethanol

N₁,N₂-bis((1H-benzotriazol-1-yl)methyl)-benzene-1,2-diamine

formaldehyd

1,2-diamino-benzene

Refernces

• 1、 Rivera, Augusto,Maldonado, Mauricio,Ríos-Motta, Jaime,Navarro, Miguel Angel,González-Salas, Diego. "Novel access to 1-substituted-benzimidazoles via benzotriazole-mediated synthesis". experimental part. p. 102 - 104. Retrieved 2010/03/03.