N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

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Chemical Name:N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide
CAS No.:1314863-40-5
Molecular Formula:C₃₃H₂₈F₃N₅O₃
Molecular Weight:599.612
Hs Code.:

Synonyms:N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

There total 3 articles about N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 677704-58-4
4-(morpholin-4-yl)-3-(trifluoromethyl)benzoic acid

: 1314863-23-4
N-(1-(4-amino-2-methylphenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

: 1314863-40-5
N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.04.031

Reference yield:

: 1314863-21-2
N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

: 1314863-40-5
N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 80 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.04.031

Reference yield:

: 98-88-4
benzoyl chloride

: 1314863-40-5
N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropylamine / acetonitrile / 8 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 80 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2011.04.031