N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

Base Information

• Chemical Name: N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide
• CAS No.: 1314863-21-2
• Molecular Formula: C₂₁H₁₆N₄O₃
• Molecular Weight: 372.383
• Mol file: 1314863-21-2.mol

Synonyms:N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

Chemical Property of N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide

There total 1 articles about N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride (1314863-19-8) + benzoyl chloride (98-88-4) → N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide (1314863-21-2)

Guidance literature:

With diisopropylamine; In acetonitrile; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.031

Reference yield:

N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide (1314863-21-2) → 1-(4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl)-3-(2,3-dichlorophenyl)urea (1314863-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

2: tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2011.04.031

Reference yield:

N-(1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl)benzamide (1314863-21-2) → N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-3-(trifluoromethyl)benzamide (1314863-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 2 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 80 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.04.031

upstream raw materials:

1-(2-methyl-4-nitrophenyl)-1H-pyrrolo[3,2-c]pyridin-4-amine hydrochloride

benzoyl chloride

Downstream raw materials:

1-(4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl)-3-(2,3-dichlorophenyl)urea

N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-3-(trifluoromethyl)benzamide

N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-chloro-3-(trifluoromethyl)benzamide

N-[4-(4-benzamido-1H-pyrrolo[3,2-c]pyridin-1-yl)-3-methylphenyl]-4-morpholino-3-(trifluoromethyl)benzamide