6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

Base Information

Chemical Name:6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide
CAS No.:1350352-19-0
Molecular Formula:C₂₄H₁₆F₄N₆O₂S
Molecular Weight:528.49
Hs Code.:

Synonyms:6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

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Chemical Property of 6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

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Technology Process of 6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

There total 7 articles about 6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1350352-18-9
6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carbonitrile

: 1350352-19-0
6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

Guidance literature:: With sulfuric acid; water; at 20 ℃; for 18h;

Reference yield:

: 1350351-79-9
6-(2-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidine

: 1350352-19-0
6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / acetone / 3 h / 20 °C

2: N,N-dimethyl-formamide / 0.5 h / 175 °C / Microwave vial

3: sodium hydride / N,N-dimethyl-formamide / 14 h / 20 °C

4: water; sulfuric acid / 18 h / 20 °C

With N-iodo-succinimide; sulfuric acid; water; sodium hydride; In N,N-dimethyl-formamide; acetone;

Reference yield:

: 1350351-92-6
2-(4-methoxy-2-trifluoromethylphenyl)-5-triisopropylsilanyloxymethyl-[1,3,4]thiadiazole

: 1350352-19-0
6-(2-fluorophenyl)-3-[5-(4-methoxy-2-trifluoromethylphenyl)-[1,3,4]thiadiazol-2-ylmethyl]-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: pyridine / dichloromethane / 1 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 14 h / 20 °C

4: water; sulfuric acid / 18 h / 20 °C

With pyridine; sulfuric acid; tetrabutyl ammonium fluoride; water; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;