160427-15-6

Basic information

• Product Name: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester
• Synonyms: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester
• CAS NO: 160427-15-6
• Molecular Weight: 235.24
• Mol File: 160427-15-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester(160427-15-6)
• EPA Substance Registry System: 3-(4-Hydroxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid ethyl ester(160427-15-6)

Safety Data

• Hazardous Substances Data: 160427-15-6(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 140-88-5 ethyl acrylate 
• 699-06-9 4-hydroxybenzaldehyde oxime 

Downstream Products

• 160427-19-0 2-Hydroxy-4-(4-hydroxy-phenyl)-4-oxo-butyric acid ethyl ester 
• 54851-73-9 6-(4-hydroxyphenyl)-3(2H)-pyridazinone 
• 160427-23-6 4-Hydroxy-6-(4-hydroxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one 

Relevant articles and documents

Generation of nitrile oxides under nanometer micelles built in neutral aqueous media: Synthesis of novel glycal-based chiral synthons and optically pure 2,8-dioxabicyclo[4.4.0]decene core

(Chemical Equation Presented) A highly efficient strategy for chemoselective oxidation of aldoximes to nitrile oxides by iodosobenzene in neutral aqueous media is reported. Their in situ intermolecular 1,3-dipolar cycloaddition (1,3-DC) with olefins in nanometer aqueous micelles occurs with improved stereoselectivity and acceleration of reaction rate toward synthesis of new chiral synthons, 3-(2′-C-3′,4′,6′-tri-O- benzylglycal)-Δ2-isoxazolines and others. Construction of optically pure 2,8-dioxabicyclo[4.4.0]decene skeleta is performed by this green approach, and the stereochemistry of the new chiral center is predicted by B3LYP density functional theory.

Nitrile oxide [3+2] cycloaddition: Application to the synthesis of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones

An efficient method for the preparation of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones starting from 3,5-disubstituted 4,5-dihydroisoxazoles is described. N-O bond cleavage of the isoxazoline ring promoted