(2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate
• CAS No.: 1239695-59-0
• Molecular Formula: C₂₈H₃₁NO₃
• Molecular Weight: 429.559

Synonyms:(2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate

Chemical Property of (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate

There total 2 articles about (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 2-methyl (2S,5R)-5-phenylpyrrolidine-1,2-dicarboxylate + phenylmagnesium chloride (100-59-4) → (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate (1239695-59-0)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.tet.2018.11.030

Reference yield:

C28H31NO3 → (2S,5S)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate (1239695-58-9) + (2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate (1239695-59-0)

Guidance literature:

isomer's separation;

DOI:10.1002/ejoc.201000336

Reference yield:

(2S,5R)-tert-butyl 2-(hydroxydiphenylmethyl)-5-phenylpyrrolidine-1-carboxylate (1239695-59-0) → diphenyl[(2S,5R)-5-phenylpyrrolidin-2-yl]methanol (1552271-22-3)

Guidance literature:

With ethanol; sodium hydroxide; for 48h; Reflux;

DOI:10.1016/j.tet.2018.11.030

upstream raw materials:

phenylmagnesium chloride

Downstream raw materials:

[(2S,5R)-1-methyl-5-phenylpyrrolidin-2-yl]diphenylmethanol

diphenyl[(2S,5R)-5-phenylpyrrolidin-2-yl]methanol

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